在城市社区预防性传播感染 (秘鲁PREVEN):一个多组件社区随机对照试验
Patricia J García1, King K Holmes, César P Cárcamo
1Epidemiology, STD/AIDS Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
Lancet (London, England)
|February 21, 2012
概括
一项多组件干预措施显示,在秘鲁的城市年轻人和女性性工作者 (FSW) 中,有潜力减少可治愈的性传播感染 (STIs). 在年轻女性和FSW中观察到显著的减少,这表明有针对性的战略是有效的.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 之前的社区随机试验对性传播感染干预措施仅限于农村环境,结果各不相同.
- 本研究探讨了对城市人口,特别是年轻人和女性性工作者 (FSW) 进行多元干预的需求.
研究的目的:
- 评估多组分干预对可治愈性传播感染 (STIs) 对城市年轻人和FSW的影响.
- 评估加强综合征管理,移动推广,假设治疗和避孕套推广的有效性.
主要方法:
- 一个社区随机试验,涉及20个匹配的秘鲁城市,以及干预和控制组.
- 在2002年进行了基线性STI查,并在2年和3年后进行后续调查.
- 干预措施包括加强性传播感染综合征管理,为FSWs提供移动外展服务,对三病的推定治疗和避孕套推广.
主要成果:
- 年轻成年人中可治愈性传播感染综合患病率的非显著降低 (RR 0.84,95% CI 0.69-1.02;p=0.096).
- 在干预城市的年轻成年女性和FSW的子组分析中,观察到性病发病率的显著降低.
结论:
- 多组件干预,包括综合症管理,FSW宣传和避孕套推广,可能会减少可治愈性传播感染的流行率.
- 有针对性的干预措施显示出对弱势城市人口中控制性传播感染的前景.
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