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IDH1突变足以确定质瘤高甲基化剂表型

Sevin Turcan1, Daniel Rohle, Anuj Goenka

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Nature
|February 21, 2012
PubMed
概括

异酸脱酶1 (IDH1) 突变通过改变甲基组和转录组,驱动质瘤中的CpG岛甲基器表型 (CIMP). 这一发现澄清了质瘤CIMP的分子基础及其对癌症发展和患者存活率的影响.

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