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恐惧调节和灭绝对树突脊柱重塑的相反影响

Cora Sau Wan Lai¹, Thomas F Franke, Wen-Biao Gan

¹Molecular Neurobiology Program, Skirball Institute, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.

|February 21, 2012

概括

恐惧调节消除了树突性棘,而恐惧灭绝则在小鼠前皮层中形成了新的棘. 这些相反的突触变化表明,恐惧记忆可能被部分删除,而不仅仅是抑制.

科学领域:

神经科学是一个神经科学.
突触性可塑性突触性可塑性
记忆研究记忆研究

背景情况:

传统上,恐惧灭绝被视为一种抑制旧记忆的新学习.
部分删除恐惧记忆的假设仍在调查中.
了解恐惧学习和灭绝期间的突触变化至关重要.

研究的目的:

为了研究神经电路修改在恐惧学习和灭绝过程中.
检查V层金字塔神经元中 postsynaptic树突棘的形成和消除.
为了将突触重塑与行为恐惧反应相关联.

主要方法:

在小鼠中利用了跨骨双光子显微镜.
检查了前额关联皮质中的树突性脊柱动态.
配对听觉线索与脚震用于恐惧调节,并单独呈现线索用于灭绝.

主要成果:

恐惧调节增加了树突性脊柱的消除.
恐惧灭绝增加了树突脊柱的形成.
突触变化以提示和位置特定的方式发生,灭绝形成了接近被消除的棘.
重新修复优先消除新形成的脊柱.

结论:

恐惧的调节和灭绝在个别突触上引起了相反的变化.
这些突触修饰与行为恐惧表达和灭绝相关.
研究结果表明,恐惧记忆的痕迹在灭绝过程中被部分删除,这挑战了仅抑制模型.

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