相关实验视频

Updated: Apr 28, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

脂质传感器GPR120的功能障碍导致老鼠和人类的肥胖

Atsuhiko Ichimura¹, Akira Hirasawa, Odile Poulain-Godefroy

¹Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.

|February 21, 2012

概括

G蛋白结合受体120 (GPR120) 通过感知食脂肪来调节能量平衡至关重要. 在小鼠和人类中,GPR120功能的丧失导致肥胖和相关的代谢障碍.

科学领域:

代谢性疾病研究研究.
分子内分泌学分子内分泌学
肥胖研究的研究.

背景情况:

自由脂肪酸是重要的能量来源和信号分子.
G-蛋白结合受体 (GPCRs) 介导脂肪酸信号传递.
GPR120 (O3FAR1) 是参与恒温的不和脂肪酸的受体.

研究的目的:

研究GPR120在调节能量平衡中的作用及其对肥胖的影响.
为了确定GPR120缺乏在小鼠中的生理后果.
为了检查GPR120表达和人类肥胖的遗传变异.

主要方法:

缺乏GPR120的小鼠模型被食高脂肪饮食.
对脂肪细胞分化,脂质生成和肝脂质生成的分析.
评估胰岛素信号传递和脂肪组织炎症.
人类脂肪组织GPR120表达分析.
在肥胖人群中进行GPR120外因子测序.

主要成果:

缺乏GPR120的小鼠表现出肥胖,葡萄糖不耐受和脂肪肝.
减少脂肪细胞分化和脂质生成,在缺陷小鼠中增强肝脂质生成.
缺乏胰岛素的小鼠的胰岛素抵抗与胰岛素信号受损和脂肪炎症增加有关.
人类GPR120表达在肥胖个体中更高.
在GPR120中发现了一种有害突变 (p.R270H),影响信号传输,增加肥胖风险.

结论:

GPR120在感知食脂肪和控制能量平衡方面发挥着至关重要的作用.
缺乏GPR120有助于代谢功能障碍和肥胖.
GPR120 p.R270H 变种与人类肥胖风险增加有关.

更多相关视频

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice

Published on: May 24, 2018

Assessing Whole-Body Lipid-Handling Capacity in Mice

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

相关概念视频

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...