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IDH突变损害了基因组脱甲基化,并导致细胞分化的阻断

Chao Lu1, Patrick S Ward, Gurpreet S Kapoor

  • 1Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Nature
|February 21, 2012
PubMed
概括

突变的异酸脱酶 (IDH) 酶产生2 - 基酸盐 (2HG),该酶通过抑制基因素脱甲基化来阻止细胞分化. 这一发现对了解质瘤等IDH突变癌症有意义.

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