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相关概念视频

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...

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相关实验视频

Updated: May 24, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

转录因子c-Maf控制触摸受体的发育和功能.

Hagen Wende1, Stefan G Lechner, Cyril Cheret

  • 1Developmental Biology, Max Delbrück Center (MDC) for Molecular Medicine, Berlin, Germany.

Science (New York, N.Y.)
|February 21, 2012
PubMed
概括
此摘要是机器生成的。

转录因子c-Maf对于触觉至关重要. 它的突变破坏了机械受体的发育和功能,影响了小鼠和人类的高频振动检测.

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Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans
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Using Facial Electromyography to Assess Facial Muscle Reactions to Experienced and Observed Affective Touch in Humans

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Last Updated: May 24, 2026

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

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科学领域:

  • 神经科学是一个神经科学.
  • 分子生物学分子生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 触觉涉及机械感应神经元检测机械刺激.
  • 有限的分子数据阻碍了对机械受体发育,多样性和功能的理解.

研究的目的:

  • 研究转录因子c-Maf在机械传感功能中的作用.
  • 确定机械受体发育和多样性的关键分子参与者.

主要方法:

  • 对c-Maf突变小鼠进行分析,以研究机械受体的发育和功能.
  • 评估帕西尼亚体细胞形态和对高频振动的敏感性.
  • 对具有c-MAF基因突变的人体实验的检查.

主要成果:

  • c-Maf对于小鼠和人类的机械感知功能至关重要.
  • 在c-Maf突变小鼠中,快速适应的机械受体 (包括帕奇尼细胞体) 的发育和功能受到干扰.
  • 在c-Maf突变小鼠中,Pacinian体细胞缩,与具有c-MAF突变的人类高频振动敏感性降低相关.

结论:

  • 转录因子c-Maf是机械受体发育和功能的关键调节者.
  • c-Maf指定了机械受体及其相关末端器官的发育和功能.
  • 这一发现为触觉多样性和功能的基础提供了分子洞察力.