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一个单位突变 (F429H) 将CYP 2B4酶转化为血红素氧酶:一个QM/MM研究

Dandamudi Usharani1, Costantino Zazza, Wenzhen Lai

  • 1Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel.

Journal of the American Chemical Society
|February 24, 2012
PubMed
概括

细胞染色体P450 2B4 (CYP 2B4) 到F429H的突变改变了O-OH键裂变. 突变酶通过同溶性裂变表现出类似血红氧酶的活性,使高效的半氧化成为可能.

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