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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

6
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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相关实验视频

Updated: Feb 15, 2026

Computer-based Multitaper Spectrogram Program for Electroencephalographic Data
04:13

Computer-based Multitaper Spectrogram Program for Electroencephalographic Data

Published on: November 13, 2019

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开放计算机程序的情况.

Darrel C Ince1, Leslie Hatton, John Graham-Cumming

  • 1Department of Computing Open University, Walton Hall, Milton Keynes MK7 6AA, UK. d.c.ince@open.ac.uk

Nature
|February 24, 2012
PubMed
概括
此摘要是机器生成的。

科学出版物越来越依赖于计算方法,但软件共享仍然不一致. 发布源代码对于计算科学中的可重现性至关重要,因为保留它会阻碍结果验证.

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科学领域:

  • 计算科学是一种计算科学.
  • 科学传播是科学传播.
  • 研究中的可复制性研究中的可复制性

背景情况:

  • 科学出版物经常省略关键证据,限制了充分的理解.
  • 越来越依赖计算科学引入了新的可访问性障碍.
  • 目前关于共享研究数据的政策不一致,特别是在软件方面.

研究的目的:

  • 倡导在计算科学中强制发布源代码.
  • 突出现行法规中关于软件可用性研究的不一致性.
  • 强调代码共享对于确保科学成果可重复性的重要性.

主要方法:

  • 关于科学数据和软件共享当前实践的文献综述.
  • 分析计算方法对研究可重复性的影响.
  • 基于开放科学和科学诚信原则的论证方法.

主要成果:

  • 数据共享越来越受欢迎,但软件可用性规定不一致.
  • 隐源代码显著增加了复制研究结果的失败尝试的风险.
  • 由于硬件和软件变化等因素,准确的可复制性本质上是不确定的.

结论:

  • 源程序的发布应该被认为对计算结果至关重要,只有少数例外.
  • 不一致的软件可用性规定对科学透明度和可重复性构成威胁.
  • 促进对源代码的开放访问对于推进可靠和可验证的科学传播至关重要.