相关实验视频
Updated: May 24, 2026

11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
疾病耐受性作为一种防御策略
Ruslan Medzhitov1, David S Schneider, Miguel P Soares
1Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA. ruslan.medzhitov@yale.edu
概括
疾病耐受性,作为宿主防御策略,减少了感染对健康的影响. 了解这种被忽视的机制为传染病和其他疾病提供了新的治疗方法.
科学领域:
- 免疫学 免疫学 免疫学
- 宿主-病原体相互作用
- 传染性疾病 传染性疾病
背景情况:
- 免疫系统主要是消除病原体.
- 宿主生物还可以减轻感染对健康的负面影响.
- 耐病性是一种研究不足的宿主防御策略.
研究的目的:
- 介绍"耐病性"作为免疫学的一个关键概念.
- 扩大对宿主-病原体相互作用的理解.
- 探索疾病的新治疗途径.
主要方法:
- 疾病耐受性的概念分析.
- 审查关于宿主防御机制的现有文献.
- 确定宿主-病原体相互作用的被忽视的方面.
主要成果:
- 耐病性是一种独特且被低估的宿主防御策略.
- 整合疾病耐受性扩大了免疫学研究的范围.
- 疾病耐受性机制对于宿主生存和福祉至关重要.
结论:
- 疾病耐受性是宿主防御的关键,但被忽视的组成部分.
- 对疾病耐受机制的进一步研究是必不可少的.
- 这个概念为传染病和其他疾病提供了新的治疗点.
相关概念视频
Special Features of Adaptive Immunity
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Defense Against Bacterial Pathogens
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Cell-mediated Immune Responses
Overview
Transduction
Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...
Defenses Against Pathogens and Herbivores
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
Desensitization and Tachyphylaxis
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...
Several...

