细胞基础的GABA(B) 介导的半球间抑制
Lucy M Palmer1, Jan M Schulz, Sean C Murphy
1Physiologisches Institut, Universität Bern, Bühlplatz 5, CH-3012 Bern, Switzerland.
Science (New York, N.Y.)
|February 25, 2012
概括
由GABA(B) 受体介导的半球间抑制,使金字塔神经元通过顶端树突沉默. 这种metabotropic抑制对于皮质输出至关重要,并依赖于神经元活动.
科学领域:
- 神经科学是一个神经科学.
- 细胞神经科学 细胞神经科学
- 感官系统 感官系统
背景情况:
- 半球间抑制通过状通路调节皮层竞争.
- 长时间的抑制与GABA(B) 受体有关,但在细胞水平上了解不够.
研究的目的:
- 阐明长期内半球抑制的细胞机制.
- 研究GABA(B) 受体在抑制神经元发射中的作用.
主要方法:
- 从老鼠体感皮质第5层金字塔神经元的电生理记录.
- 刺激相对侧和相对侧感觉通路.
- 对作用于角树突的抑制机制的分析.
主要成果:
- 由对侧感官刺激引起的金字塔神经元的发射被阻碍了数百毫秒的ipsilateral刺激.
- 抑制直接发生在顶端树突上,通过1层内部神经元.
- 抑制过程依赖于金字塔细胞的激发,利用活性树突电流的metabotropic抑制.
结论:
- 这项研究揭示了潜在的半球间抑制的微电路.
- 活性树突性质对于通过这种抑制机制调节皮质输出至关重要.
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