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Updated: May 12, 2026

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
11:06

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

一个分化检查点限制了血液造血干细胞的自我更新,以应对DNA损伤

Jianwei Wang1, Qian Sun, Yohei Morita

  • 1Institute of Molecular Medicine and Max-Planck-Research Department of Stem Cell Aging, University of Ulm, Ulm, Germany.

Cell
|March 6, 2012
PubMed
概括

DNA 损伤触发了一个检查点,限制了干细胞的自我更新. 研究人员确定了基本的氨酸拉链转录因子,ATF类 (BATF) 作为这一过程的关键,影响造血干细胞 (HSC) 和潜在的衰老.

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Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells14:37

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