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在神经退行性大脑中,认知功能的表观遗传阻塞

Johannes Gräff1, Damien Rei, Ji-Song Guan

  • 1Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Nature
|March 6, 2012
PubMed
概括

神经退行性疾病中的认知障碍是由基因转录的表观遗传阻断引起的. 这种阻塞,由基因素脱乙酶2 (HDAC2) 介导,可以逆转,恢复记忆功能.

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