对于不对称的烯化的C1-对称 bis(imino) 皮里丁合金复合体
Sebastien Monfette1, Zoë R Turner, Scott P Semproni
1Department of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
新的催化剂能够对烯酸进行反选择性化. 这些C(1)-对称的bis(imino) 皮里丁复合物在不对称的合成中实现了高选择性,从而推进了催化方法.
科学领域:
- 有机金属化学 有机金属化学
- 不对称的催化剂.
- 协调化学 协调化学
背景情况:
- 性催化剂对于合成性纯化合物至关重要.
- 双胺连接物为过渡金属提供了多功能协调环境.
- 复合物越来越多地被探索为贵金属催化剂的经济有效替代品.
研究的目的:
- 为了合成和描述新型的C(1)-对称 bis(imino) 皮里丁合金复合物.新型的C(1)-对称 bis(imino) 皮里丁合金.
- 为了研究这些复合物的催化活性在enantioselective化反应.
- 评估它们在 geminal-disubstituted olefins 的不对称合成中的有效性.
主要方法:
- 合成C(1) -对称 bis((imino) 皮里丁复合物 (化物,甲基,化物,环金属化物).
- 使用光谱和分析技术进行表征.
- 测试 geminal-disubstituted olefins 的 enantioselective 化中的催化性能.
主要成果:
- 成功合成并完全描述了多种类型的enantiopure复合物.
- 在化反应中表现出高的催化活性和酶选择性.
- 确定与催化效率相关的特定复杂结构.
结论:
- 乙酸C(1)-对称 bis(imino) 皮里丁复合物是不对称化的有效催化剂.
- 这些发现为开发高效的化催化剂提供了新的平台.
- 这项研究有助于推进enantioselective合成方法的发展.
更多相关视频
10:21Developing Photosensitizer-Cobaloxime Hybrids for Solar-Driven H2 Production in Aqueous Aerobic Conditions
Published on: October 5, 2019
19:58Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
相关概念视频
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
Reduction of Alkenes: Catalytic Hydrogenation
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the surface of...
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Regioselectivity and Stereochemistry of Hydroboration
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn stereochemistry.
Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
