Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Bayesian Optimization of Catalysis with In-Context Learning.

ACS central science·2026
Same author

A multi-agent system for automating scientific discovery.

Nature·2026
Same author

MDCrow: automating molecular dynamics workflows with large language models.

Machine learning: science and technology·2026
Same author

A mu-opioid receptor positive allosteric modulator provides opioid-sparing antinociception without enhancing opioid side effects.

The Journal of pharmacology and experimental therapeutics·2026
Same author

Not All Math Activities Are Equal in Terms of Gender Stereotypes.

Sex roles·2026
Same author

Looking back and to the future after four-plus years of language in chemistry.

Digital discovery·2026

相关实验视频

Updated: May 24, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

类自我组装单层的序列,结构和功能.

Ann K Nowinski1, Fang Sun, Andrew D White

  • 1Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, USA.

Journal of the American Chemical Society
|March 10, 2012
PubMed
概括
此摘要是机器生成的。

一个四残留链接器 (-PPPPC) 改善了黄金上的自组合单层 (SAM),创造了有序的结构并减少了蛋白质吸附. 这为控制细胞粘附提供了一个更简单的替代品,而不是聚乙烯甘醇.

更多相关视频

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
09:54

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

相关实验视频

Last Updated: May 24, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides
09:54

Synthesis and Characterization of 1,2-Dithiolane Modified Self-Assembling Peptides

Published on: August 20, 2018

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

科学领域:

  • 生物材料科学 生物材料科学
  • 表面化学 表面化学
  • 纳米技术 纳米技术

背景情况:

  • 囊是一种常见的选择,用于将质附着在黄金表面上.
  • 体自组装单层 (SAM) 对于各种表面功能化应用至关重要.
  • 实现具有高表面密度的有序SAM对于最佳性能至关重要.

研究的目的:

  • 为了研究一个刚性,疏水的四残留链接器 (-PPPPC) 对SAM结构和功能的影响.
  • 为了比较具有-PPPPC链接器 (EKEKEKE-PPPPC-Am) 的的性能与氨酸终结 (EKEKEKE-C-Am) 的性能.
  • 评估 -PPPPC链接器在不使用聚乙烯糖醇的情况下控制特定细胞粘附的潜力.

主要方法:

  • 循环二重化 (CD) 光谱法 循环二重化 (CD) 光谱法
  • 减弱的总内部反射里埃变换红外光谱学 (ATR-FTIR)
  • 分子动力学 (MD) 模拟
  • 表面等离子体共振 (SPR) 传感器
  • 在X射线光电子光谱学 (XPS) 中.

主要成果:

  • -PPPPC链接器促进了具有二次结构的有序 SAMs 的形成,与囊终结形成的随机结构不同.
  • 与氨酸终结相比,具有-PPPPC链接器的体表现出明显较低和更一致的蛋白质吸附.
  • XPS证实了两种类型的的强烈金-结合,并将功能差异归因于SAM结构.
  • -PPPPC链接器在较短的链接器 (-PC, -PPC, -PPPC) 上显示出更高的性能.
  • 具有RGD序列的功能化 (EKEKEKE-PPPPC-Am) 能够控制特定细胞粘附.

结论:

  • 加入一个刚性,疏水的四残留链接器 (-PPPPC) 是一种优越的策略,用于在黄金表面上创建有序和密集的SAM.
  • 这种链接器策略增强了表面的非污染性质,并为控制细胞粘附的传统方法提供了可行的替代方案.
  • -PPPPC链接器为基于的表面工程提供了一个多功能平台,避免了复杂的化学物质.