风湿性心脏病是一种心脏病
Eloi Marijon1, Mariana Mirabel2, David S Celermajer3
1Paris Cardiovascular Research Centre, INSERM U970, European Georges Pompidou Hospital, Paris, France; Department of Cardiology, European Georges Pompidou Hospital, Paris, France; Paris Descartes University, Paris, France; Maputo Heart Institute (ICOR), Maputo, Mozambique.
Lancet (London, England)
|March 13, 2012
概括
风湿性心脏病 (RHD) 在全球范围内导致年轻人严重的心血管死亡. 通过查和抗生素预防的早期检测是管理发展中国家这个被忽视的疾病的关键.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 风湿性心脏病 (RHD) 是年轻人心血管疾病和死亡的主要原因,特别是在发展中国家.
- 它源于遗传敏感宿主对A组链球菌感染的自身免疫反应,导致不可逆转的心脏膜损伤.
- 在全球范围内,RHD每年造成大约25万例死亡,这对公共卫生造成了巨大的负担.
研究的目的:
- 强调风湿性心脏病 (RHD) 在发展中国家的重大影响.
- 为了强调由于资源限制而管理先进的RHD所面临的挑战.
- 探索可行和具有成本效益的RHD预防和早期检测策略.
主要方法:
- 对有关风湿性心脏病 (RHD) 流行病学和管理的现有文献的审查.
- 对抗生素预防急性风湿性发烧的有效性和成本效益的分析.
- 讨论潜在的查策略,包括积极监测和心声回声学,对于处于危险的人群.
主要成果:
- 青素预防在预防复发性急性类风湿性发烧方面是有效和具有成本效益的,这是RHD的前身.
- 先进的RHD阶段的治疗资源密集,对新兴国家的医疗保健系统构成挑战.
- 通过查在特有地区面临风险的人群的早期检测被提出为一个可行的策略.
结论:
- 抗生素预防是治疗风湿性心脏病 (RHD) 的关键策略,通过预防复发性急性风湿性发烧.
- 在流行病地区,主动监测和基于心声学的查对早期RHD检测和有针对性的干预有前途.
- 解决RHD需要政策制定者和媒体的更多关注,因为它对全球健康产生重大影响,特别是在年轻人群中.
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