将癌症疗法转化为治疗方法:从传染病中吸取教训
Michael S Glickman1, Charles L Sawyers
1Infectious Diseases Service and Immunology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. glickmam@mskcc.org
Cell
|March 20, 2012
概括
癌症药物耐药性反映了传染病的挑战. 结合疗法和向持久细胞是克服治疗失败和预防这两个领域复发的关键.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 癌症药物开发已经转向向治疗,但暂时反应和耐药性仍然是重大挑战.
- 耐药性是癌症和传染病治疗失败的主要原因,需要新的治疗策略.
- 了解传染病中的抵抗机制为改善癌症治疗提供了宝贵的见解.
研究的目的:
- 为了比较和对比癌症和传染病中耐药性机制.
- 探索如何使用针对病毒和细菌感染的策略可以为癌症治疗提供信息.
- 确定消除耐药性持久细胞和瘤发起细胞以防止复发的方法.
主要方法:
- 在癌症和传染病中对抗性机制的比较分析.
- 对克服艾滋病毒和结核病的治疗策略的审查.
- 讨论协同效应的组合疗法和向持久性/干细胞.
主要成果:
- 癌症和传染病在发展耐药性方面具有相似的挑战.
- 组合疗法对于最大限度地提高两个领域的初始治疗反应至关重要.
- 针对耐药性持久细胞 (传染病) 和瘤发起/干细胞 (癌症) 是长期缓解的关键.
结论:
- 从传染病研究中学到的经验教训,特别是关于组合治疗和向持久细胞的经验教训,可以指导更合理的癌症治疗.
- 开发药物来消除耐药性持续性和瘤发起细胞对于预防晚期复发和缩短癌症和传染病治疗时间至关重要.
- 一种统一的方法来打击跨学科的耐药性,有望改善患者的治疗结果.
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