在皮肤透光冠状动脉血管塑造期间适应缺血. 临床,血液动力学和代谢特征
E Deutsch1, M Berger, W G Kussmaul
1Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia.
Circulation
|December 1, 1990
概括
在血管造形术期间的第二次冠状动脉封闭表明缺血减少. 这表明心脏适应短暂的血流减少,这种现象被称为缺血预先调节.
科学领域:
- 心脏病学 心脏病学
- 生理学 生理学 生理学
背景情况:
- 皮肤透光冠状动脉血管造形术 (PTCA) 涉及暂时的冠状动脉封闭.
- 了解心脏对重复性缺血的反应对于患者的治疗结果至关重要.
研究的目的:
- 调查PTCA期间对连续冠状动脉封闭的临床,心电图和血液动力学反应.
- 在重复的闭塞期间检查心肌乳酸代谢.
主要方法:
- 接受PTCA的12名患者出现了左前下垂冠状动脉90秒的连续封闭.
- 心肌乳酸代谢在7名患者的单独组中进行了评估.
主要成果:
- 与第一个相比,第二次闭塞导致了较少的胸不适,ST段转移和较低的肺动脉压力.
- 在第二次闭塞期间,心脏静脉流量和心肌乳酸生产显著减少.
- 这些发现表明对缺血的保护性适应.
结论:
- 在第二次闭塞期间心肌缺血的证据减少支持缺血预先调节的概念.
- 缺血预调可能在PTCA等干预程序期间提供一种保护机制.
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