饥饿引起的休息代谢率对triiodothyronine的敏感性下降
概括
在所有被测试的老鼠中,饥饿减少了休息时的氧气消耗,包括那些患有甲状腺功能低下症的老鼠. 在甲状腺功能低下的老鼠中,三甲氨酸治疗效果较差,表明代谢反应发生了变化.
科学领域:
- 生理学 生理学 生理学
- 内分泌学 在内分泌学.
- 代谢过程中的代谢.
背景情况:
- 甲状腺激素调节新陈代谢率和氧气消耗.
- 众所周知,饥饿会降低能源消耗.
- 甲状腺功能低下症的特征是甲状腺激素水平降低.
研究的目的:
- 为了研究饥饿对休息时氧气消耗的影响,在euthyroid和hypothyroid大鼠.
- 评估三甲状腺氨酸治疗对低甲状腺大鼠在饥饿期间的氧气消耗的影响.
主要方法:
- 鼠 (甲状腺和甲状腺功能下降) 被 subjected to starvation. 被 subjected to starvation. 鼠 (甲状腺和甲状腺功能下降) 被 subjected to starvation. 鼠 (甲状腺功能下降和甲状腺功能下降) 被 subjected to starvation. 鼠 (甲状腺功能下降和甲状腺功能下降) 被 subjected to starvation. 鼠 (甲状腺功能下降和甲状腺功能下降) 被 subjected to starvation.
- 测量了休息时间的氧气消耗.
- 甲状腺功能低下的小鼠接受了三甲状腺素治疗.
主要成果:
- 饥饿降低了休息时的氧气消耗在euthyroid大鼠.
- 饥饿也降低了甲状腺功能低下小鼠的休息氧气消耗.
- 在低甲状腺小鼠中,triiodothyronine在正常化氧气消耗方面的有效性降低了.
结论:
- 在饥饿期间减少休息氧气消耗是不同甲状腺状态的保存反应.
- 甲状腺功能低下症可能会损害身体利用甲状腺激素进行代谢调节的能力,即使在营养缺乏期间也是如此.
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