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Updated: May 23, 2026

Isolation of Ribosome Bound Nascent Polypeptides in vitro to Identify Translational Pause Sites Along mRNA
10:15

Isolation of Ribosome Bound Nascent Polypeptides in vitro to Identify Translational Pause Sites Along mRNA

Published on: July 6, 2012

反Shine-Dalgarno序列驱动了细菌的转化暂停和编码子选择

Gene-Wei Li1, Eugene Oh, Jonathan S Weissman

  • 1Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA.

Nature
|March 30, 2012
PubMed
概括

令人惊的是,细菌的翻译速度受到编码区域内的Shine-Dalgarno (SD) 序列的影响,而不是罕见的转移RNA. 这一发现揭示了内部SD类序列如何通过影响蛋白质合成率来驱动基因组进化.

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