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Updated: May 23, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

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Published on: May 22, 2014

GBP5促进了NLRP3炎症酶组合和哺乳动物的免疫力

Avinash R Shenoy1, David A Wellington, Pradeep Kumar

  • 1Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

Science (New York, N.Y.)
|March 31, 2012
PubMed
概括

关酸结合蛋白5 (GBP5) 是一种新型蛋白质,可激活NLRP3炎症体,对免疫反应至关重要. 这一发现扩大了我们对炎细胞组合和宿主防御机制的理解.

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...