人类皮质表面积的等级遗传组织
Chi-Hua Chen1, E D Gutierrez, Wes Thompson
1Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.
概括
科学家利用遗传学绘制了人类大脑皮层的地图,以揭示大脑区域. 这本遗传图谱揭示了大脑区域的层次和模块化组织,为人类大脑发育提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 人类遗传学 人类遗传学
- 脑部成像 脑部成像
背景情况:
- 皮层表面积是高度遗传的,但对其区域差异化的遗传影响在很大程度上是未知的.
- 了解对大脑结构的遗传控制对于破译人类大脑发育和进化至关重要.
研究的目的:
- 为了确定人类大脑皮层的遗传定义的细分.
- 根据遗传数据创建一个新的人类大脑地图.
- 研究基因影响皮层区域的组织原理.
主要方法:
- 在406名双胞胎的磁共振成像 (MRI) 数据上使用了数据驱动的模糊集群技术.
- 将皮层表面积分为基因上不同的细分.
- 开发了一份基因信息为基础的人类大脑图谱.
主要成果:
- 鉴定了大脑皮层的遗传细分,这些细分在很大程度上与已知的结构和功能区域保持一致.
- 发现了新的现象型和皮质区域的层次,模块化组织.
- 在整个半球的遗传组织中表现出主要的双边对称性.
- 发现人类特异性区域是在更广泛的基因基因叶片模式中的细分.
结论:
- 这项研究介绍了人类大脑皮层的新,基因衍生地图.
- 皮层表面积表现出一个层次,模块化和对称的遗传组织.
- 这些发现为人类大脑差异化的遗传结构提供了新的见解.
相关概念视频
Organization of the Brain
The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...
Motor and Sensory Areas of the Cortex
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex.
Somatosensory, Motor, and Association Cortex
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at the...
Cerebrum: Anatomical Overview II
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
Association Areas of the Cortex
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Lobes of the Cerebrum
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements.


