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Updated: May 23, 2026

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice
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恶性质瘤:从基因组学,小鼠模型和干细胞中吸取教训

Jian Chen1, Renée M McKay, Luis F Parada

  • 1Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|April 3, 2012
PubMed
概括

恶性质瘤是一种常见的大脑瘤,通常是无法治愈的. 最近的研究揭示了新的遗传驱动因素和分子标记物,改善了瘤分类和治疗策略.

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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...