口服诺基诺和视网膜脱落的风险
Mahyar Etminan1, Farzin Forooghian, James M Brophy
1Therapeutic Evaluation Unit, Child and Family Research Institute of British Columbia, Vancouver, Canada. metminan@popi.ubc.ca
JAMA
|April 5, 2012
概括
目前使用口服诺,一种常见的抗生素,与视网膜脱落的风险增加有关. 然而,这种严重的眼睛疾病的总体绝对风险仍然很小.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 口服诺基诺是被广泛处方的抗生素,具有已知的眼部毒性.
- 之前的研究主要集中在病例报告上,缺乏大规模的药物流行病学数据,了解视网膜脱落风险.
研究的目的:
- 调查口服诺基诺使用与发展视网膜脱落的风险之间的关联.
- 量化与当前,最近和过去使用诺基诺相关的视网膜脱落风险.
主要方法:
- 从2000年至2007年,在不列颠哥伦比亚省的一组患者中进行了一项嵌套病例控制研究.
- 视网膜脱落病例是通过外科手术程序编码识别的,每个病例的10个对照对应.
- 该研究分析了当前,最近或过去口服诺基诺使用与视网膜脱落之间的关联.
主要成果:
- 这项研究确定了4384例视网膜脱落病例和43840例对照病例,从989,591名患者的队列中.
- 目前使用诺基诺显示,视网膜脱落的风险显著增加 (调整率比率[ARR],4.50).
- 无论是最近还是过去使用诺基诺都与风险增加无关;绝对风险增加为每10,000人年4人.
结论:
- 与不使用相比,口服诺基诺的使用与视网膜脱落的风险增加有关.
- 与诺基诺使用相关的视网膜脱落的绝对风险很小.
- 视网膜脱落和β-乳酸抗生素或β-激动剂之间没有发现任何关联.
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