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Updated: May 23, 2026

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直接酸生物结合/PEGylation 在氨酸与线性和分支的聚合物二氧化盐

Mathew W Jones1, Giuseppe Mantovani, Claudia A Blindauer

  • 1Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.

Journal of the American Chemical Society
|April 13, 2012
PubMed
概括

这项研究表明,特定地点的聚合物与酸铁残留物的结合,增强了药物输送. 由此产生的结合物在体外和体内都保持了生物活性.

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.