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Updated: May 23, 2026

Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function
11:50

Retroviral Transduction of Helper T Cells as a Genetic Approach to Study Mechanisms Controlling their Differentiation and Function

Published on: November 4, 2016

全基因组表观遗传标记和转录控制的动态转换确定了T细胞的身份

Jingli A Zhang1, Ali Mortazavi, Brian A Williams

  • 1Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA.

Cell
|April 17, 2012
PubMed
概括

这项研究揭示了转录因子GATA-3和PU.1如何通过调节基因表达和表观遗传标记来控制T细胞发育. 它揭示了T细胞承诺期间基因激活和抑制的动态机制.

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Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines11:39

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines

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