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聚A结合蛋白核1抑制了替代裂变和多基化位点

Mathias Jenal1, Ran Elkon, Fabricio Loayza-Puch

  • 1Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Cell
|April 17, 2012
PubMed
概括

聚A结合蛋白核1 (PABPN1) 抑制了替代裂变和多化 (APA),这是一个关键的基因调节过程. 丢失PABPN1导致3'未翻译区域缩短,并影响微RNA调节.

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