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Updated: May 6, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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一个无序的片段的立体特异性结合介导了BK通道不活化

Vivian Gonzalez-Perez1, Xu-Hui Zeng, Katie Henzler-Wildman

  • 1Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.

Nature
|April 24, 2012
PubMed
概括

本质上无序的蛋白质部分调解关键功能,如离子通道不活化. 这项研究揭示了两种不同的分子相互作用,即立体特异结合和直接封闭,这些基本的生物过程的基础.

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