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相关概念视频

Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
Rab Cascades01:25

Rab Cascades

Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
Three-Compartment Open Model01:06

Three-Compartment Open Model

The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...

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相关实验视频

Updated: May 23, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

一个有三个部分的化学驱动的分子信息杆.

Armando Carlone1, Stephen M Goldup, Nathalie Lebrasseur

  • 1School of Chemistry, University of Edinburgh, UK.

Journal of the American Chemical Society
|April 25, 2012
PubMed
概括

这项研究引入了罗塔克桑信息. 状催化剂控制了宏循环沿着轨道的方向运动,展示了分子运输的新方法.

科学领域:

  • 超分子化学 超分子化学
  • 分子机器分子机器
  • 有机化学 有机化学

背景情况:

  • 罗塔克桑是分子组合,其宏循环线在轴上.
  • 信息杆利用外部刺激来实现分子层面的定向运动.
  • 在分子系统中控制定向运输对于开发先进的分子设备至关重要.

研究的目的:

  • 设计和表征一个三隔间的罗塔信息.
  • 展示使用性催化剂来对分子运动进行定向控制的方法.
  • 为了研究催化剂性对宏观循环的运输的影响.

主要方法:

  • 合成一个三间隔的罗塔xane 系统.
  • 使用基于性4-二甲基亚胺胺 (DMAP) 的催化剂.
  • 采用化反应来诱导宏循环的移位.
  • 使用光谱技术分析宏观周期的方向传输.

主要成果:

  • 罗塔克桑信息杆使宏循环沿着状轨道进行定向运输.
  • 化DMAP催化剂有效地促进了化反应.
  • 性催化剂的手性决定了宏循环被运送到的主要末端隔间.
  • 基于催化剂性,实现了宏循环的主要单向运动.

更多相关视频

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
11:20

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology

Published on: January 24, 2018

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

相关实验视频

Last Updated: May 23, 2026

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
11:20

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology

Published on: January 24, 2018

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

结论:

  • 状催化剂可用于控制罗塔xane系统中分子运输的方向性.
  • 这项工作提出了一种新的方法,即使用催化剂控制的定向运动来控制信息.
  • 开发的系统为分子开关和逻辑门的应用提供了潜在的潜力.