异构,形状持久,超大分子蝶结构和蝶结构的自组合
Anthony Schultz1, Xiaopeng Li, Balaka Barkakaty
1Department of Chemistry, The University of Akron, Akron, Ohio 44325, USA.
Journal of the American Chemical Society
|April 26, 2012
概括
研究人员使用新型特皮里丁连接物创建了两种新的分子形状,一种蝶结和一种蝶. 这些构成性异构体通过控制自我组装条件来分离,并以其独特的离子移动性分离漂移时间而闻名.
科学领域:
- 超分子化学 超分子化学
- 有机合成 有机合成
- 分析化学 分析化学
背景情况:
- 二连接物是超分子化学中的多功能构建块.
- 在多组件系统中控制自我组装对于创建复杂架构至关重要.
- 木合是一种强大的合成复杂有机分子的方法.
研究的目的:
- 为了合成新的特皮里丁配体.
- 为了实现两个不同的宏分子组成异构体的受控自组合.
- 用分析技术来表征得到的同位素并区分它们.
主要方法:
- 通过苏苏基合,高产二胺配体的合成.
- 为选择性自组装优化一个三组件系统.
- 使用电子喷射电离质谱法 (ESI-MS),移动波离子运动质谱法 (TWIM-MS),质子核磁共振 ((1) H NMR) 和碳-13核磁共振 ((13) C NMR) 的表征.
主要成果:
- 成功合成了以前未报告的特皮里丁配体.
- 两种新型宏分子构成异构体的分离:一个分子蝶结和它的蝶图案.
- 清晰的特征数据,包括离子移动性分离的显著不同的漂移时间,证实了结构差异.
结论:
- 新型特皮里丁连接物使不同宏分子异构体的受控自组合成为可能.
- 离子移动性分离是有效的区分这些结构异构体基于大小和形状.
- 这项工作为设计和合成具有精确控制的复杂超分子架构提供了一条途径.
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