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Recombinant Retroviral Production and Infection of B Cells
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Published on: February 18, 2011

由AID驱动的删除会导致B细胞中的免疫球蛋白重链位点自杀重组

Sophie Péron1, Brice Laffleur, Nicolas Denis-Lagache

  • 1Limoges University, CNRS, 2 rue Marcland, 87025 Limoges Cedex, France.

Science (New York, N.Y.)
|April 28, 2012
PubMed
概括

激活诱导脱氨酶 (AID) 在免疫球蛋白基因中触发了一种新的DNA重组. 这种"位点自杀重组"会删除恒定区域基因,影响B细胞存活率和恒常性.

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