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拨下SUN1对于层状病变来说

Yousin Suh1, Brian K Kennedy

  • 1Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Cell
|May 1, 2012
PubMed
概括

甲型核膜的突变会导致层状病变,这是一组包括进发性病和肌肉衰竭在内的疾病. 核内膜蛋白SUN1的高表达在这些条件下驱动病理.

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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...