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Updated: May 1, 2026

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
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Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Published on: December 10, 2015

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内核包膜蛋白Sun1的积累在进发性和变质性层状病变中具有病原性

Chia-Yen Chen1, Ya-Hui Chi, Rafidah Abdul Mutalif

  • 1National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|May 1, 2012
PubMed
概括

LMNA基因的突变会导致肌肉发育不良和前列腺症等层状病变. 在小鼠模型和患者细胞中减少Sun1蛋白积累,意外地改善了健康和寿命,使Sun1与这些疾病有关.

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