用尿素功能化的M4L6受体:在水溶液中以阳离子模板自组合和选择性客交换
Radu Custelcean1, Peter V Bonnesen, Nathan C Duncan
1Chemical Sciences Division, Oak Ridge National Laboratory, Tennessee 37831-6119, United States. custelceanr@ornl.gov
Journal of the American Chemical Society
|May 2, 2012
概括
新型M(4)L(6) 体受体选择性地从水中结合四面体氧化离子 (EO(4) ((n-)). 功能化的子展示了基于形状,大小和电荷的离子识别,模板自组装影响了选择性.
科学领域:
- 超分子化学 超分子化学
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
背景情况:
- 分子的新设计对于开发选择性宿主-客系统至关重要.
- 四面体协调提供了独特的结构图案,用于分子识别.
- 阳离子结合和传感仍然是化学中的重大挑战.
研究的目的:
- 设计和合成用于选择性阴离子封装的新型M(4) L(6) 受体.
- 研究这些子的自我组装,结构特征和离子结合特性.
- 阐明控制四面体oxoanion识别选择性的因素.
主要方法:
- 合成和特征的M(4) L(6) (M = Ni, Zn) 与内部尿素组.
- 光谱技术包括多核NMR ((1) H, (13) C, (77) Se) 和扩散NMR.
- 电子喷雾电离质谱 (ESI-MS),紫外线光谱和单晶X射线衍射.
- 理论计算以了解子结构和自组装.
- (77) 对于离子交换选择性研究的NMR光谱学.
主要成果:
- 成功合成和特征M(4) L(6) 子与内部尿素组用于离子结合.
- 根据大小,形状和电荷,证明了四面体氧离子 (EO(4) ((n-)) 的选择性封装.
- 观察到,子的自组装是由oxoanions模板,在离子去除后,子重新排列.
- 建立了一个离子选择性趋势:PO(4)(3-) ≫ CrO(4)(2-) > SO(4)(2-) > SeO(4)(2-) > MoO(4)(2-) > WO(4)(2-).
- 确定了影响选择性的因素,包括离子电荷,大小,水分,基本性和键受体能力.
结论:
- 具有内部尿素组的新型M(4) L(6) 子是水溶液中四面体氧化的有效受体.
- 阳离子选择性由多种因素组成,包括互补性,灵活性和特定的阳离子特性.
- 模板自组装机制为这些协调的形成和稳定提供了洞察力.
- 这些发现有助于开发用于离子识别和传感的先进材料.
相关概念视频
Ion Exchange
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...
EDTA: Chemistry and Properties
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
Complexation Equilibria: The Chelate Effect
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
Ligand Binding Sites
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Pore Transport and Ion-Pair Transport
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...


