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一个统一的模型,用于mTORC1-介导的mRNA翻译调节

Carson C Thoreen1, Lynne Chantranupong, Heather R Keys

  • 1Department of Cancer Biology, Dana Farber Cancer Institute, 250 Longwood Avenue, Boston, Massachusetts 02115, USA.

Nature
|May 4, 2012
PubMed
概括

猛素复合体1 (mTORC1) 的哺乳动物标选择性地控制了具有5'终端寡聚胺 (TOP) 基因的信使RNA (mRNA) 的翻译. 这种调节由4E结合蛋白 (4E-BPs) 和eIF4G1调节,影响细胞生长.

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