与年龄相关的黄斑变性
Laurence S Lim1, Paul Mitchell, Johanna M Seddon
1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Lancet (London, England)
|May 8, 2012
概括
与年龄相关的黄斑变性 (AMD) 是导致失明的主要原因,影响超过20%的老年人. 早期诊断和治疗,如抗VEGF注射,可以减缓这种常见的眼病导致的视力损失.
科学领域:
- 眼科医生 眼科 眼科
- 老年病的医生 老年病的医生
- 遗传学 是一个遗传学.
背景情况:
- 与年龄相关的黄斑变性 (AMD) 是全球不可逆转失明的重要原因,特别影响老年人群.
- 先进的AMD,包括湿性神经血管AMD和地理缩 (晚期干燥AMD),导致严重的,渐进的视力丧失.
- 关键的危险因素包括吸烟,营养,心血管健康以及补充,脂质和血管路径中的遗传倾向.
研究的目的:
- 审查与年龄相关的黄斑变性疾病的流行率,风险因素,诊断和当前/未来的治疗方法.
- 突出人口老龄化对AMD患病率的影响以及识别可修改的风险因素的重要性.
- 讨论诊断方式和治疗策略,包括抗VEGF药物和新兴的再生选择.
主要方法:
- 对流行病学数据,风险因素,诊断技术和AMD治疗干预措施的文献综述.
- 对当前治疗结果的分析,包括抗VEGF疗法,如拉尼比祖马布和贝瓦西祖马布.
- 探索新兴和未来的治疗途径,如再生和局部疗法.
主要成果:
- 患AMD的患病率很高,随着人口老龄化而增加,尽管一些研究表明可能与可修改的风险因素减少有关.
- 准确的诊断依赖于临床检查与视网膜摄影,血管学和光学连贯性断层扫描相结合.
- 饮食中的抗氧化剂可以减缓AMD的进展,而眼内抗VEGF注射是湿性AMD的标准,拉尼比祖马布和贝瓦齐祖马布的疗效相似.
结论:
- 与年龄相关的黄斑变性病的有效管理需要早期诊断和干预,而抗VEGF治疗是湿 AMD 的基石.
- 了解遗传和可修改的风险因素对于预防和治疗策略至关重要.
- 目前正在进行的新疗法研究,包括再生和局部治疗,为AMD管理的改善结果提供了希望.
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