在弗雷明汉心脏研究中,运动血压反应与心血管风险因素和血管功能之间的关系
George Thanassoulis1, Asya Lyass, Emelia J Benjamin
1National Institutes of Health/National Heart, Lung, and Blood Institute’s Framingham Heart Study, Framingham, MA 01702, USA.
Circulation
|May 11, 2012
概括
血管功能受损,包括动脉硬和内皮功能障碍,与更高的运动血压 (BP) 有关. 这表明血管问题可能导致心血管疾病风险增加.
科学领域:
- 心血管生理学心血管生理学
- 血管生物学 血管生物学
- 运动医学 运动医学
背景情况:
- 运动血压 (BP) 是心血管健康的关键指标,预测左心室缩,高血压和未来的心血管事件.
- 虽然血管功能受损被怀疑会影响运动BP,但基于社区的数据仍然有限.
研究的目的:
- 为了研究血管功能测量和运动血压 (BP) 响应之间的关联,在基于社区的队列中.
- 为了确定与运动相关的特定血管参数,抽缩和腹缩血压.
主要方法:
- 利用了从2115名参与者 (弗雷明汉子女队伍) 接受亚最大运动测试 (布鲁斯协议) 的数据.
- 通过平面化度测量和臂动脉流量介导扩张评估血管功能.
- 采用多变量线性回归来将运动BP与心血管风险因素和血管措施相关联.
主要成果:
- 运动时的缩血压与年龄,站立血压,心率,吸烟,体重指数和胆固醇比例正相关.
- 关节-关节脉冲波速,中心脉冲压,平均动脉压和基线臂流与缩性运动血压有积极的关联.
- 流媒体扩张与运动静脉血压有负相关性,而前向压力波幅和平均动脉压与运动静脉血压有关.
结论:
- 动脉硬度增加和内皮功能受损与较高的缩血压有显著的相关性.
- 研究结果表明,血管功能受损可能会在日常活动中导致过度的血压反应,从而增加心血管疾病的风险.
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