BMP8B通过中央和外围的作用增加棕色脂肪组织热生成
Andrew J Whittle1, Stefania Carobbio, Luís Martins
1Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, UK. ajw232@cam.ac.uk
Cell
|May 15, 2012
概括
骨形态遗传蛋白8B (BMP8B) 直接调节棕色脂肪组织 (BAT) 的热生成,并影响能量平衡. 这种蛋白质可能为代谢障碍提供一种新的治疗点.
科学领域:
- 代谢研究的研究.
- 内分泌学 在内分泌学.
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- 棕色脂肪组织 (BAT) 的热生成对于哺乳动物的能量平衡至关重要.
- 骨形态遗传蛋白 (BMP) 是已知的脂肪生成的调节者.
- 在规范成熟的BAT热生成中,BMPs的具体作用仍然在很大程度上未被探索.
研究的目的:
- 研究骨形态遗传蛋白8B (BMP8B) 在棕色脂肪组织中直接调节热生成中的作用.
- 阐明BMP8B影响能量消耗和代谢率的分子机制.
- 检查BMP8B对参与食欲和能量恒温的下丘脑信号通路的影响.
主要方法:
- 使用Bmp8b淘汰 (Bmp8b(-/-)) 鼠标模型来评估热生成和代谢表型.
- 在成熟的BAT中研究了BMP8B对上腺素诱导反应的影响,包括信号通路 (p38MAPK/CREB) 和脂酶活性.
- 分析了bmp8b的神经水平和AMP激活蛋白激酶 (AMPK) 在Bmp8b的下丘脑中的化.
- 进行中央BMP8B治疗,以评估其对BAT交感激活和下丘脑AMPK状态的影响.
主要成果:
- Bmp8b(-/-) 小鼠表现出BAT热生成受损,代谢率降低,尽管食物摄入量减少,但体重显著增加 (缺食).
- 在成熟的BAT中诱导BMP8B通过p38MAPK/CREB信号传递和增加脂酶活性增强了诺亚上腺素反应.
- Bmp8b(-/-) 鼠标显示下丘脑神经形状发生变化,AMPK酸化减少,这表明它们处于厌食状态.
- 中央BMP8B的管理刺激了BAT的同情活动,这取决于下丘脑AMPK信号传递.
结论:
- BMP8B被确定为一种关键的热生成蛋白,它直接调节棕色脂肪组织中的能量消耗.
- BMP8B与下丘脑AMPK协同作用,维持能量平衡,影响能量消耗和食欲.
- BMP8B为增加能量消耗和对抗肥胖等代谢疾病提供了潜在的治疗目标.
更多相关视频
08:31Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
2.6K
04:46Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
Published on: February 3, 2023
2.3K
相关概念视频
Body Temperature
3.8K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
3.8K
Adrenergic Receptors: β Subtype
3.8K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
3.8K
Metabolic Rate
1.5K
The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
1.5K
Thermoregulation
3.0K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
3.0K
