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Updated: May 4, 2026

Ex Vivo Imaging of Cell-specific Calcium Signaling at the Tripartite Synapse of the Mouse Diaphragm
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Ex Vivo Imaging of Cell-specific Calcium Signaling at the Tripartite Synapse of the Mouse Diaphragm

Published on: October 4, 2018

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通过Arc/Arg3.1与CaMKIIβ的动态相互作用来对非活跃突触进行反向突触标记

Hiroyuki Okuno1, Kaori Akashi, Yuichiro Ishii

  • 1Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan. okuno@m.u-tokyo.ac.jp

Cell
|May 15, 2012
PubMed
概括

研究人员发现Arc蛋白如何向不活跃的突触,防止不必要的增强. 这一发现澄清了Arc在突触可塑性和AMPA受体调节中的作用.

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A High-content Assay for Monitoring AMPA Receptor Trafficking

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Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy10:41

Visualizing Protein Kinase A Activity In Head-fixed Behaving Mice Using In Vivo Two-photon Fluorescence Lifetime Imaging Microscopy

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相关概念视频

Calmodulin-dependent Signaling01:16

Calmodulin-dependent Signaling

Calmodulin (CaM) is a calcium-binding protein in eukaryotes that controls various calcium-regulated cellular processes. It has four calcium-binding sites that bind calcium to form the calcium-calmodulin ( Ca2+-CaM) complex. GPCR stimulation increases the calcium levels in the cells that bind to CaM and induces a conformational change.
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
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