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Updated: May 3, 2026

A Fluorescence-based Exonuclease Assay to Characterize DmWRNexo, Orthologue of Human Progeroid WRN Exonuclease, and Its Application to Other Nucleases
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通过准REX1进行降解,RNF12启动X染色体不活化

Cristina Gontan1, Eskeatnaf Mulugeta Achame, Jeroen Demmers

  • 1Department of Reproduction and Development, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

Nature
|May 19, 2012
PubMed
概括

在胎盘哺乳动物中,E3泛基因酶RNF12降解了多能性因子REX1,从而启动了X染色体不活化. 这种RNF12-REX1通路对于雄性和雌性哺乳动物之间的基因剂量补偿至关重要.

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