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Contrast-Matching Detergent in Small-Angle Neutron Scattering Experiments for Membrane Protein Structural Analysis and Ab Initio Modeling
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在aquaporin-0周围建模洗剂组织,使用小角度X射线散射

Alice Berthaud1, John Manzi, Javier Pérez

  • 1Institut Curie, Centre de Recherche, CNRS UMR168, Université Pierre et Marie Curie, F-75248 Paris Cedex, France.

Journal of the American Chemical Society
|May 25, 2012
PubMed
概括

洗剂在膜蛋白周围形成保护冠状,阻碍了结构研究. 这项研究使用SAXS精确地模拟了这种洗剂冠状,从而使未来的膜蛋白的结构分析成为可能.

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Aquaporins01:25

Aquaporins

Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.