氧素是昼夜节律的保存标记物
Rachel S Edgar1, Edward W Green, Yuwei Zhao
1Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Nature
|May 25, 2012
概括
过氧化氧化-减氧循环是所有生命领域中昼夜节律的通用标记. 这一发现揭示了细胞计时和氧化还原平衡之间存在着深厚的联系,在地球的大氧化事件后演变.
科学领域:
- 生物化学 生物化学
- 进化生物学 进化生物学
- 时间生物学 时间生物学
背景情况:
- 细胞生命起源于37亿年前,陆地生物适应了由地球旋转驱动的日常循环.
- 内生昼夜节律进化为同步内部生理与外部环境循环.
- 昼夜节律的分子基础很难研究,因为细菌,古生物和真核生物中缺乏保存的时钟基因.
研究的目的:
- 为了确定一个普遍的分子标志物为昼夜节律在生活的各个领域.
- 研究代谢氧化还原循环和昼夜计时机制之间的联系.
- 了解昼夜节律和氧化还原平衡的共同进化.
主要方法:
- 在多种模型生物中描述过氧化蛋白氧化-减少周期的振荡.
- 分析新陈代谢周期和昼夜系统中的转录-翻译反循环之间的相互作用.
主要成果:
- 过氧素蛋白的氧化-减氧循环被确定为细菌,古生物和真核生物中昼夜节律的保存,通用标记物.
- 在这些氧化还原循环和各种生物体内核心时钟机制之间观察到相互连接.
- 这些发现表明,昼夜计时与氧化还原平衡一起进化.
结论:
- 过氧化氧化还原循环为所有生命领域的昼夜节律提供了一个基本的,进化保守的基础.
- 循环节计时与细胞氧化还原平衡密切相关,可能是在大氧化事件后共同演变的.
- 这一发现为生物钟的古老起源和普遍机制提供了新的视角.
相关概念视频
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Peroxisomes
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Peroxisomes and Mitochondria
Peroxisomes and mitochondria are two important oxygen-utilizing organelles in eukaryotic cells. Mitochondria carry out cellular respiration—the process that converts energy from food into ATP. Peroxisomes carry out a variety of functions, primarily breaking down different substances, such as fatty acids.
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within peroxisomes...
The peroxisome is a single membrane-bound cellular organelle that can perform several different functions, including lipid metabolism and chemical detoxification. The enzymes within peroxisomes...
Peroxisomes
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
Redox Reactions
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...

