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Updated: May 5, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

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通过eIF2α-P的持续转化抑制调解子神经退行

Julie A Moreno1, Helois Radford, Diego Peretti

  • 1MRC Toxicology Unit, Hodgkin Building, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

Nature
|May 25, 2012
PubMed
概括

持续的蛋白质错折导致神经元死亡,因为它关闭了蛋白质合成. 恢复蛋白质翻译速率,防止神经退行,并改善小鼠的生存率.

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相关概念视频

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Nonsense-mediated mRNA Decay02:27

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The Unfolded Protein Response01:37

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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
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