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开发一种Grp94抑制剂

Adam S Duerfeldt1, Laura B Peterson, Jason C Maynard

  • 1Department of Medicinal Chemistry, The University of Kansas, Lawrence, Kansas 66047, USA.

Journal of the American Chemical Society
|May 31, 2012
PubMed
概括

准热冲击蛋白90 (Hsp90) 提供了治疗癌症的潜力. 一种新型抑制剂选择性地向Grp94,一个ER-居民的Hsp90,避免了泛Hsp90抑制剂所见的有毒效应.

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Eukaryotic Transcription Inhibitors01:52

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Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
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