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Updated: May 13, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes
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Generation of Genetically Modified Mice through the Microinjection of Oocytes

Published on: June 15, 2017

在小鼠中,基因重组是远离功能性基因组元素的

Kevin Brick1, Fatima Smagulova, Pavel Khil

  • 1National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892, USA.

Nature
|June 5, 2012
PubMed
概括

PRDM9蛋白通常将基因重组指向特定的热点. 在缺少它的情况下,重组仍然发生,但被重新定向到基因促进器和其他基因组位点.

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Use of Freeze-thawed Embryos for High-efficiency Production of Genetically Modified Mice06:46

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