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甲基化粉样ββ的类行为和tau依赖性细胞毒性

Justin M Nussbaum1, Stephan Schilling, Holger Cynis

  • 1Department of Biology, University of Virginia, Charlottesville, Virginia 22904, USA.

Nature
|June 5, 2012
PubMed
概括

甲基氨基酸β-β (pE-Aβ) 通过形成依赖陶为神经元死亡的有毒寡合体来启动阿尔茨海默病. 这些pE-Aβ寡合体通过类似子的机制传播,驱动疾病的病原性.

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...