AMPK调节NADPH稳态,在能量压力期间促进瘤细胞存活

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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Published on: May 30, 2012

Sang-Min Jeon1, Navdeep S Chandel, Nissim Hay

  • 1Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA.

Nature
|June 5, 2012
PubMed
概括

通过调节NADPH水平,AMPK激活有助于癌细胞在代谢压力下生存. 这一途径对于瘤生长和在能量有限的条件下生存至关重要.

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