补充物C1q激活了正规的Wnt信号,并促进了与衰老相关的表型
Atsuhiko T Naito1, Tomokazu Sumida, Seitaro Nomura
1Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Japan.
Cell
|June 12, 2012
概括
补充C1q激活Wnt信号,加速衰老和阻碍组织修复. 阻止C1q或其基因可以恢复再生,揭示C1qq.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 老年学是指老年学的学科.
背景情况:
- Wnt信号对于发育和疾病至关重要.
- 增强的Wnt信号与哺乳动物的衰老有关.
- 补充C1q在衰老中的作用尚不清楚.
研究的目的:
- 研究补充C1q在Wnt信号传递中的作用.
- 为了确定C1q是否影响与衰老相关的组织再生的下降.
主要方法:
- 在老化野生型和C1qa缺乏的小鼠中评估血清C1q度和Wnt信号活动.
- 研究了C1q的Wnt激活机制,包括受体结合和蛋白质分裂.
- 研究了外源C1q对年轻小鼠骨肌肉再生的影响.
- 评估了C1s抑制和C1qa基因干扰对与衰老相关的肌肉再生障碍的影响.
主要成果:
- 在野生型小鼠中,血清C1q度和Wnt信号活动随年龄而增加,但在C1qa缺乏的小鼠中并非如此.
- 补充C1q与Frizzled受体结合,并诱导LRP6的C1s依赖性分裂,激活了正规的Wnt信号传递.
- 外源C1q抑制了年轻小鼠的骨肌肉再生.
- 抑制C1s或破坏C1qa基因恢复了与衰老相关的肌肉再生.
结论:
- 补充物C1q意外地激活了正规的Wnt信号.
- C1q有助于与衰老相关的组织再生的下降.
- 准C1q可能为与年龄相关的再生障碍提供治疗策略.
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