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无果会招募两个对抗性色素因子来建立单个神经元的性二态
Hiroki Ito1, Kosei Sato, Masayuki Koganezawa
1Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai, Japan.
Cell
|June 12, 2012
概括
德洛索菲拉无果 (果) 基因
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 发育生物学 发展生物学
背景情况:
- 德洛索菲拉无果 (果) 基因对男性的性行为和性二态神经元电路的发展至关重要.
- 果实确定神经元性命运的精确分子机制尚未完全理解.
研究的目的:
- 阐明无果 (果) 基因确定神经元性命运的机制.
- 为了确定参与神经元中介性分化的分子参与者.
主要方法:
- 研究了水果蛋白与其他细胞因子的相互作用.
- 分析了Fru-Bon复合体对染色体调节者的招募.
- 研究了操纵HDAC1和HP1a表达对神经元性命运的影响.
主要成果:
- 果实与转录辅因子Bonus (Bon) 形成一个复合体.
- 弗鲁-邦复合物用于男性化使用的基因脱乙酶1 (HDAC1) 或用于脱男性化神经元的异染色蛋白1a (HP1a).
- 改变HDAC1或HP1a水平会改变男性与女性典型神经元的比例,这表明在单个神经元水平上决定了全部或没有的性命运.
结论:
- 果仁复合体作为一个中央开关,利用HDAC1和HP1a来确定个体神经元的性命运.
- 神经元性命运的决定是一个全部或没有的过程,而不是跨性别特征的光谱.
- 这项研究揭示了由染色质修饰剂调节的特定性别神经元发育的新机制.
相关概念视频
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The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions take up more dye, appearing darker, while the less-compact areas take up less dye and appear lighter. Based on the compaction level, chromatins are classified into two primary forms – euchromatin and heterochromatin.
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Evolution
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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
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Heterochromatin
The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...
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