跨年龄和地理位置的人类肠道微生物组
Tanya Yatsunenko1, Federico E Rey, Mark J Manary
1Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA.
Nature
|June 16, 2012
概括
人类肠道微生物组的发展显示了不同人群的共享模式. 然而,美国居民和委内瑞拉和马拉维的个人之间出现了细菌组成和基因含量的显著差异,突出了环境影响.
科学领域:
- 微生物学 微生物学
- 人类遗传学 人类遗传学
- 人口健康 人口健康
背景情况:
- 肠道微生物群落有助于人类的遗传和代谢多样性.
- 了解特定人群微生物群的差异对于人类健康研究至关重要.
研究的目的:
- 来自不同人群的便样本中的细菌物种和基因含量.
- 研究不同地理位置和生活方式的儿童和成年人肠道微生物如何不同.
主要方法:
- 从531个个体的便样本中分析细菌物种组成.
- 110个个体的功能基因含量的表征.
- 来自委内瑞拉亚马逊,马拉维农村和美国大都会地区的微生物组数据的比较,包括双胞胎.
主要成果:
- 在人口中确定了肠道微生物组在生命的前三年功能成熟的共同特征.
- 观察到与维生素生物合成和新陈代谢相关的基因的年龄相关变化.
- 美国居民和委内瑞拉和马拉维的个人之间细菌组合和功能基因库的明显差异,从婴儿期到成年期显而易见.
结论:
- 肠道微生物组的组成和功能在西方化和非西方化人群之间有很大差异.
- 这些差异在生命的早期显而易见,并持续到成年.
- 考虑微生物组对于理解人类发展,营养,生理学以及西方化的影响至关重要.
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