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新德里金属β-乳糖酶:对β-乳糖的识别和抑制的结构见解

Dustin T King1, Liam J Worrall, Robert Gruninger

  • 1Department of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia, Canada V6T 1Z3.

Journal of the American Chemical Society
|June 21, 2012
PubMed
概括

新德里金属β-乳糖酶-1 (NDM-1) 酶赋予了对关键β-乳糖抗生素的耐药性. 结构分析揭示了NDM-1如何与碳烯和抑制剂相互作用,指导新药的开发.

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